Bridging the gaps in nanosafety for animal-free prediction of adverse outcomes

Efficient and cost-effective risk-assessment for particulate matter & nanotech products

The current problem

Current animal-based safety assessment is too slow and costly for industry and regulators to test all nano-sized materials entering the market and environment.


3-6 months

Adverse outcome

The solution

The EU-funded nanoPASS project will design new screening approaches for inhalation hazards based on early key events that lead to adverse outcomes.


1 week

Prediction of adverse outcome

More about us

Goals and objectives

Prediction of 4 adverse outcomes related to inhalation of particulate matter:

  1. Reduced lung function
  2. Lung fibriosis
  3. Cardiovascular disease
  4. Neurodegeneration
  • New in vitro models of key events
  • New detection of key event dynamics
  • New outcome prediction algorithms
  • Calibration of prediction against in vivo data
  • Validation with diverse real-life industrial materials (construction, plastics, electronics, medical)

Our partners

Jožef Stefan Institute

Jožef Stefan Institute is the leading Slovenian research organisation. It is responsible for a broad spectrum of basic and applied research in the fields of natural sciences and technology. In Laboratory of Biophysics,  we are responsible for quantitative detection of dynamics of early key events in vitro with advanced optical microscopy methods, and for development of new in vitro models.

Role in the project:

Quantitative detection of dynamics of early key events with in vitro high-resolution & high-throughput advanced optical microscopy methods and development of new in vitro models.

Infinite Biotech

Infinite is a research - focused biotech spin-out from the Jožef Stefan Institute and a leading developer of predictive toxicology technology based on in vitro molecular event quantification and in silico time propagation.

Role in the project:

Infinite is responsible for developing animal test alternatives for chronic lung inflammation utilizing predictive toxicology technology.

Helmholtz Munich

Helmholtz Munich develops solutions for a healthier future. 

Role in the project:

Identification of early key events with in vivo intravital microscopy 


The National Research Centre for the Working Environment (NFA) is a government research institute under the Danish Ministry of Employment which conducts research at the highest international level to:

  • provide consultancy services within the institute’s core areas
  • perform development work with a clear social aim
  • disseminate research-based knowledge to workplaces, authorities, the social partners and safety consultants
  • participate in the training of researchers and educational activities at the universities within its core areas.

Role in the project:

  • AOP development
  • In vivo studies for validation of in vitro models
  • development of in vitro models for prediction of nanomaterial toxicity


STAMI is the National Institute of Occupational Health in Norway. It is responsible for providing research-base knowledge on the Norwegian working life in order to prevent illness and promote good health among workers.

Role in the project:

Development of in vitro and in silico models, providing industrial test nanomaterials.



National University of Ireland, University College Dublin

Role in the project:

In silico characterisation of nanomaterials, development of models for prediction of nanomaterial toxicity.


The Nanotechnology Industries Association (NIA) is the cross-sectoral, responsible voice for nanotechnology value chains and the global commercial eco-system.


Alpacem is the biggest Slovenian cement producer.

Role in the project:

Alpacem – Industrial partner, provide access to the facility, decide collection locations in the production line for collection of industrial nano materials.

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