Current animal-based safety assessment is too slow and costly for industry and regulators to test all nano-sized materials entering the market and environment.
Exposure
3-6 months
Adverse outcome
The EU-funded nanoPASS project will design new screening approaches for inhalation hazards based on early key events that lead to adverse outcomes.
Exposure
1 week
Prediction of adverse outcome
Prediction of 4 adverse outcomes related to inhalation of particulate matter:
Jožef Stefan Institute is the leading Slovenian research organisation. It is responsible for a broad spectrum of basic and applied research in the fields of natural sciences and technology. In Laboratory of Biophysics, we are responsible for quantitative detection of dynamics of early key events in vitro with advanced optical microscopy methods, and for development of new in vitro models.
Role in the project:
Quantitative detection of dynamics of early key events with in vitro high-resolution & high-throughput advanced optical microscopy methods and development of new in vitro models.
Main contact persons:
Iztok Urbančič and Tilen Koklič
Infinite is a research - focused biotech spin-out from the Jožef Stefan Institute and a leading developer of predictive toxicology technology based on in vitro molecular event quantification and in silico time propagation.
Role in the project:
Infinite is responsible for developing animal test alternatives for chronic lung inflammation utilizing predictive toxicology technology.
Main contact person:
Janez Štrancar
Helmholtz Munich develops solutions for a healthier future.
Role in the project:
Develop and optimise in vitro models to mimic AOP-relevant key events
Identification of early key events with in vivo intravital microscopy
Main contact person:
Dr. Tobias Stöger and Prof. Markus Rehberg
The National Research Centre for the Working Environment (NFA) is a government research institute under the Danish Ministry of Employment which conducts research at the highest international level to:
Role in the project:
Main contact persons:
Ulla Vogel and Jorid Sørli
STAMI is the National Institute of Occupational Health in Norway. It is responsible for providing research-base knowledge on the Norwegian working life in order to prevent illness and promote good health among workers.
Role in the project:
Development of in vitro and in silico models, providing industrial test nanomaterials.
Main contact person:
Johanna Samulin Erdem
Lund University conduct research to increase our understanding of the world, make complex issues comprehensible, and address global challenges. The Lund University strategic research area NanoLund is a cross-disciplinary research organization specializing in various areas of nanoscience, among those Nanosafety.
Role in the project:
ULUND is responsible for characterizing, collecting, and distributing the industrial materials for validation of results and to prove relevance and usability for industry, and for an extended characterization of workplace exposures and risk management plan.
Main contact person:
Christina Isaxon
National University of Ireland, University College Dublin
Role in the project:
In silico characterisation of nanomaterials, development of models for prediction of nanomaterial toxicity.
Main contact person:
The Nanotechnology Industries Association (NIA) is the cross-sectoral, responsible voice for nanotechnology value chains and the global commercial eco-system.
Main contact person:
Sean Kelly
Alpacem is the only Slovenian cement producer
Role in the project:
Alpacem – Industrial partner, provide access to the facility, decide collection locations in the production line for collection of industrial nano materials.
Main contact person:
Tereza Pahor
